I wasn't a huge fan of the Antimateriel Rifle. I used it to snipe one guy from a range that would make Boone's jaw drop. I used it mainly because I imagine the effect of someone giving a speech and suddenly having their chest cavity explode and spray their audience with viscera much more satisfying to my character (who obviously worked for the Legion and was, as such, a total asshole).
I've used games to prove a point in a paper I did on censorship, as well as psychological effects. Basically, "If person A plays game A, which is very realistic (humans killing humans) and person B plays game B which isn't very realistic (non-human killing non-human/human killing non-human) does it have an effect of the person's overall aggession level? The real pain was finding people with similar personalities to play the games the same amount of time (after tutorials and whatnot) and monitor the results (which meant hanging around them for a while/having them report signs of change) and finding people that didn't normally play the games (which was hard to find people interested in playing games that they didn't already play that type of, if any games. >.>).
I prefered using a silenced sniper rifle in NV. I one shotted pretty much everyone in the dam, including those pesky black armored rangers. My armor was gone by the time I beat it, so I was left with aviator sunglasses, a first recon beret, and my underwear, when I won. I found it more than a little chuckle worthy. XD