Pistol round to the balls. That will change the nature of a man to that of a eunuch.
I've played through Planescape: Torment, and I do not like it. I am not a fan of the story, and there is little to be done to convince me that the gameplay alone is worth the time and effort.
Not to say there aren't bright spots, like Tony Jay and Nordom. But even after the Nameless One dies, he still exists. He just goes to the Blood War. Granted that sucks, but it was not a debate between existence and nonexistence, just how he spends his time. And who cares how some D-bag spends eternity if he knows he gets to have one?
You know what takes a heavy sack/tig ol' pair of bitties? Knowing that your life on Earth is all that you ever get, even if your life sucks or you're insignificant on the global scale. That guy who got your promotion by stealing your work? He might not get punished. He might bang your girlfriend instead.
The measure of a person is how she deals with real problems. And yeah, I know that's not the nature of man. Man doesn't have a nature.