Actually, nothing. There isn't a single game I'm truly looking forward to. There are a few that I might take a look at, but nothing truly interesting.
Starcraft 2 - I'm still not too keen on the whole "only one campaign" thing, and my confidence in Blizzard isn't as high as it used to be, since they haven't made a proper game in almost a decade. That being said, a decent RTS game is long overdue and the recent offerings (C&C4, SupCom2, Napoleon, etc.) have been pathetic...
Force Unleashed 2 - I liked the first game, flaws and all, but I'm not getting my hopes up because the first game took an extra year to come out on the PC...
Fallout: New Vegas - One one hand, I liked Fallout 3, and this seems like it'll be more of it. On the other hand, it's made by Obsidian, a company which hasn't put out a finished product EVER...
Forgotten Sands - I like PoP, but the previous game was kinda weak, so I'm not getting my hopes up...
Alpha Protocol - Cool premise, but again, it's by Obsidian. I'm sure it'll have a ton of great ideas in it, but it's likely to be an unfinished and buggy. I'd love to be pleasantly suprised, but I'm not holding my breath...
Beyond that, everything else that looks remotely interesting (WH40k:Space Marine, Halo: Reach, Fable 3, etc.) are console exclusives.
Perhaps I've been spoiled by the past few months, but I'd pretty much kill for a good RPG or Strategy game right about now. As it stands, I'm stuck playing Diablo 2 and emulated SNES games...