Let's see...
Top of my list is Mass Effect 3, but it's also the one I'm going to have to wait the longest for.
Next comes The Old Republic. Seems like it'll be a great game, and a great time waster.
Then Halo Reach.
Golden Sun. I loved Golden Sun when I was a kid, and now they're finally continuing the story!!!
And lastly, Portal 2. With the addition of co-op gameplay, it seems like it'll be a blast!!! I'm sure me and my friend are going to spend hours trying to think of crazy ways to kill each other while we're playing.
Oh, and also, Starcraft 2, but I won't wait long.
And I'm also waiting for the new Red vs. Blue DVD set to come out. I know it's not a game, but I'm more psyched about that then anything else listed. Well, except for Mass Effect 3.