Mass Effect 3 for sure. Dragon's Age 2 possibly. I have no doubt in Bioware's abilities to craft a delightful and engaging story with amazing dialogue and relatable characters...but I am extremely disappointed in their decision to go away from the origins model of character creation to a move Mass Effect-y model. Not that I think it's a bad way to do things...it allows them to focus on the character rather than think about infinite approaches to every single situation, but I don't think Dragon's Age 1 suffered for allowing you to pick the origin of your character. In fact, I think it was stronger for it...so let the Mass Effect "Shepherd" stay in Mass Effect and the Dragons Age "origins" stay in Dragons Age.
I'll probably give Diablo 3 a look and possibly Torchlight 2 (gee, can you tell what kinds of games I like?)
Other than that, this year looks to be mildly boring overall for games I'm interested in. I'll probably give Portal 2 a shot, but I'm likely to just rent it.