L.A. Noire with Mass Effect, solving crimes, interogating prisoners, high speed shuttle chases, and shootouts... IN SPACE!!! Hopefully you won't have to interogate any Elcor:
"I know your lying to me,"
"With barely contained terror: What proof have you got?"
Also Fallout with Red Dead Redemption, think about it, a giant, awesome post-apocalyptic tale of redemption, riding in the desert with your horse, stopping to help some stranger defend his homestead from radscorpions, meeting interesting and deep charecters and shooting stuff with them.