For me its games that deviate from their original style & generally become a mediocre shoot em up.
Metal gear 2: Snakes revenge on the NES. Good by stealth & tactical espianarge that made the original so, well, original. Hello mundane shoot em up just like the rest of them. Fortunately it was returned to its roots before it got lost down this path.
Any odd world game after Abes exodus. I havent played Munches oddyssey but I remember seeing an interview with the creator who said he wanted to make a game series that wasnt a shoot em but required puzzle & strategy. I believe its gone the way of first person shooters now, so sad.
And sadly I have to add to the list, my beloved Silent Hill series starting from Homecoming. Everyone would argue that Silent hill 4: The room is the black sheep but it was originally designed to be a completely different horror game & for some reason was converted to a silent hill title, but in all fairness I believe they did an awesome job by adapting the story line & tying it in as a spin off to SH2. Shame it didnt have the classic effect of the flashlight but it made up for it with the graphics, sound effects & music (Joe Romersa F*** Yeah!)
However, Homecoming gnaws away at my sanity & not in a good way that silent does. I mean it irritated me that the atmosphere was compromised to turn it into an action flick. That might work for Resident evil but not Silent Hill & by the looks of the sequel we can expect SH to be lost into obscurity down this path.
RIP authentic atmospheric Japanese horror. Hello mundane American survival horror action flick.*sad Sigh*