"I'll rip your head off and shit down your neck!"
Classic Duke Nukem right there

"Yippie-kay-aye, Muthaf*cka"
Aaaaah, Bruce. This is why you're my favorite actor.
"I was weak. That's why I needed you. I needed someone to punish me for my sins. But that's all over now. I know the truth. Now it's time to end this."
Whoever did the american voice acting for James deserves a medal. For a second, James sounded creepier than the music (look up Silent Hill music and understand)
"The most merciful thing in the world, I think, is the inability of the human mind to correlate all its contents."
I wish I could write something this awesome

"Ph'nglui Mglw'nafh Cthulhu Rl'yeh Wgah'nagl F'htagn"
You know you enjoy the quote if you can memorize it and pronounce it.
"I've got balls of steel!"
Words cannot describe...