I really think that the big thing is going to motion control moving closer and closer to the core gaming style. I hate motion control for my core gaming experience, but in terms of some of the smaller casual games it works. But really other than that I can't see any really major difference.
I can tell you what I don't want though:
I do not want the media format to go purely digital. Not only is it to early to really implement it, but its just a bad idea in general. How ever that is not what this thread is for so I'll save my rant.
I do not want to see any of the major three to announce that this is their last console. I think the competition is healthy (other than spawning fanboy/girls, but what can you do?).
I don't want to have to be connected to the internet to play my games (somewhere I heard a rumor about that for the Xbox 720, but I have no idea if its true)
I don't want to have to play nothing but new games. Yes I buy used, so shoot me!
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Oh and someone was wondering if anyone else was going jump into the console game, and, if I remember correctly, Apple was talking about taking another shot at a console. No major hopes there thought because from what I hear the PinPin (or whatever it was called) sucked.