I think Lovecraftian creatures would be a huge hit with everybody. Impossibly twisted fusions of every creepy body part imaginable with no rhyme or reason, their very presence disrupting the very reality around them. You can do whatever the hell you want because their nature defies any kind of definition. Sadly, it won't happen on any mass scale because it's way easier to model on top of motion-captured actors than it is to animate something completely from scratch.