"Fear of the Heavens" from Secret of Mana/Seiken Densetsu 2 (SNES 1993)
Its the game that effectively popped my 9 year old RPG cherry in the sense that it actually dealt with exp, element affinity, a storyline and stats. So, it'll always have a warm spot in my heart. Every time i hear it i feel like im about to be enveloped in a mystical and epic adventure.
God i wish another Square-Enix game would give me that feeling again....last ones were FFT Vagrant Story and FF9...
Also this gem (i had to, for great justice)
Second Place goes to Street Fighter III Third Strike: Gill's Theme
SF3 had the best fighting game music ever, this one stands out....