I'm not saying girls can't be guitar legends, but I don't think many of them have the proper motivation to do so. Men do it for fun, fame, girls and, in some cases, to establish masculinity. Why do women play? Mostly for fun it seems. Which is fine, I'm not badmouthing, I'm just pointing out what I have observed.
Also, it seems that the realm of actually music is available almost exclusively to men anyways. Composing complex music, whether it's metal or classical, seems to be of interest only to men while women create music like Lady Gaga and Taylor Swift. Most of those types of artists don't even write their own material either.