The school I was at wasn't really discriminatory of any nerd culture. If anything it kinda just became a guy fad. If you were picked on, it was more for other reasons and not because you liked a certain thing. But well, it was a somewhat expensive private school and they took bullying quite seriously.
There was some typical friction between the different cliques but they all played videogames anyway. Cliques generally stuck together and to my knowledge, violence hardly ever happened. A few people that lets just say 'stood out' might have had it worse than others, but I don't recall any full on beatings.
DnD wasn't really a thing for me, the boys in my brother's year were quite into PnP stuff. He'd rope me into some of his attempts at DMing, but I was young and didn't really understand what the hell was going on. Not sure if it was even DnD. He used to play some of the Fighting Fantasy books. He definitely wasn't ostracized or a loner in school.
Magic the Gathering was pretty popular for a while. Digimon became a thing for a few years. Pokemon largely took over for a long time. Most people played Counter-Strike. It was kinda ritual for many boys to hit up cybercafes after school.