Magic Hobo said:
Master Chief v Arbiter.
Preferably in a high-stakes battle for dominion of colonized space.
There can only be one!
Bring it on Vrex.
Oh.... believe me, I'll bring it.
The Arbiter cannot be defeated, for he is the
Prince of Sangheilios!!!!
Alright, got that outta the way, as it stands I can't think of many great punchups right now (admittedly I can imagine a great catfight between Ashley Williams of Mass Effect and Alyx Vance of Half Life 2 but those are just my immature male fantasies) so for now I shall take my leave of this thread and come back when I can think of a better example then the Arbiter totally owning any foolish human.
Wait, thought of one:
Raikou from Otogi: Myth of Demons versus Ryo Hayabusa from Ninja Gaiden.
Could be cool.
EDIT: And Urdnot Wrex versus Marcus Fenix. My money is on the awesome power of Wrexness.