Fallout: New Vegas !!!
"Aside from the normal gameplay mode, which is similar to how Fallout 3 is played, the game includes an optional "hardcore mode", in which the character needs to drink water, ammo has weight, healing isn't instant and other changes, making the game more realistic, were made"
That's just wished for but I didn't think they would ever make. I glad they have a normal mode too but I love this.