Final Fantasy VI. Most games are too long to be rendered scene for scene including this one, but in more general presentation (in the style of an Opera House of course) it could work. As my mother described after recently seeing 'Wicked', Musicals are at their best when depicting each of the primary emotions in their songs. FFVI has lots of sadness and anger, plus the occasional hope spot.
I'd also endorse this in stage form:
[video]http://www.youtube.com/watch?v=R6L9bUouDr8[/video]