The guy and girl from To The Moon have a heartbreakingly tragic story which would be utter spoilers to describe. They spent their whole lives an inch away from perfect happiness but never able to get there
.
And then you can pretty much just pick any person you like from the Metal Gear series and it's pretty much guaranteed they're pretty darn tragic. Big Boss, raised a soldier, kills
and lets the obsession with stopping it from happening overtake him until he nearly destroys the world by trying to save it, until once again it's just him and an old man with nothing left. All the enemies tend to have their homes burned down, their families killed, their lives controlled and manipulated from a young age, raised to kill and spread Fear, Pain, Joy, killing comrades and enemies alike until forced into a battle they often know is pointless but are willing to go through with anyway and will lead to their death.
Otacon who has pretty much everyone he loves ever
and unwittingly unleashed a horror onto the world whilst trying to build up nuclear deterrence.
etc
because life had made them unable to really communicate with each other
And then you can pretty much just pick any person you like from the Metal Gear series and it's pretty much guaranteed they're pretty darn tragic. Big Boss, raised a soldier, kills
his mentor and mother
Otacon who has pretty much everyone he loves ever
die
etc