Hell yeah! That's enthusiasm toward liking Powerpuff Girls, not an answer to your question. I never really discussed or fully appreciated Powerpuff Girls when I was younger, but this summer I got into it again and acquired the complete series DVDs.
Powerpuff Girls was not originally meant to be a girls' show, nor were the actual released episodes necessarily targeted at girls. Craig McCracken says so himself in some commentary on the DVD and elsewhere.
Speaking of Powerpuff Girls, here's a piece of Powerpuff Girls content that has somewhat eroded from the collective memory of the internet over time.
The trailer:
http://www.youtube.com/watch?v=p5M-V9EMG8k
The full song:
http://www.youtube.com/watch?v=9rPck4ly4Y8
Those are the only 2 videos of it on Youtube. There is only one website with lyrics to the song transcribed in existence. I have them saved on my computer just in case.
http://lampbane.livejournal.com/109105.html
I wouldn't say My Little Pony is better than Powerpuff Girls. I'm not sure which one is better, but Powerpuff Girls was definitely aimed at an older and more male audience. As good as Friendship Is Magic is, it was a unique combination of events that lead to its mass popularity.
Speaking of Powerpuff Girls and My Little Pony, here's my doodle expressing my love for both.
http://dozydagger.com/more-drawings/bubbles-on-twilight.jpg