To beat a dead horse I too will say the .32 and Chinese pistols in Fallout 3. Why would I waste ammo or inventory space on it when the other weapons (10mm pistol and Hunting Rifle) that I could get at the same point in the game are so much better? Then again, I suppose that's to make the combat even more unbalanced. I also would like to add Fallout 3's sniper rifle. Doesn't it defeat the purpose if I have to be in the enemy's face to snipe them, at which I could use a dozen different weapons? Oh well, that's what happens when Bethesda gets the last grab at a franchise.
Of course in most multiplayer FPS's, knives and handguns are worse than useless. By the time you run out of ammo for your sexy assault rifle, you end up either hoping and praying your teammates will cut down somebody else with a good gun or one of them dies, you despicable scavenging vulture. Or you run into a mob so you'll respawn with ammo again.
But to offer an original idea I will nominate the Punisher from Resident Evil 4. It only has 1.9 firepower with all upgrades, (the starter handgun get 2.0) but the selling point is supposed to be that it goes through multiple enemies. *Ahem* Enemies rarely line up 5 in a row for you to take pot shots at all of them at the same time, and in those few cases you have many alternatives including the sniper rifles, shotguns, and grenades.
