I never want to see the invasion of Normandy again, ever. We get it, we know what happens, we've seen it so many times we could all easily picture it in our minds during shock therapy.
Enough already.
I don't have a problem with Second World War setting, but dear lord it was a freak world War. Move out of Normandy, let us see the large Soviet fights for their "Great Patrotic War" and their point of view, the battles of Northen Africa, Chinese battles, the precursors to the Asian theator, the British Chanels, anything. There is more then enough to make a thousand more games, we don't need repeating the same stuff everytime.
I would also accept Conker's Bad Führer Day if made my the original RARE people, not modern day RARE.
Personaly though, the easiest way to stop me from caring in a game is to make a game setting that is just a random assortment of white, brown, black, or green textures and call it diffrent maps. Unreal Tournament mods, Halo, most sandbox games that aren't any good, and so forth just make a cannon, give it green and brown or add a gray building with white texture and tell us it's diffrent. Even worse when it's just a brown desert with stuff in the background but not much where you actualy play.
That's not a specific setting I know, but I still call it "boring".
One setting we do need more of? Art Deco Urban/ 1920s through late 1930s settings. Bioshock, Shadow Hearts, and a few others a nice, but not nearly enough.