Honestly? I don't think that's going to happen. Not in that way, anyway. We don't want to play disabled characters just to mess with controllers. Edward Elric style prosthetics? We can work with that, and I think that would be pretty awesome to have mechanical limbs that actually affect gameplay. What you are suggesting, though, seems to me as more of a "make the game harder through some gimmick that weakens our control over gameplay.
If you want different heroes based on characterization, I fully agree with you there. I don't much care for the grizzled, unfeeling space marine character, because it seems as if the point of a hero is to be badass rather than flawed nowadays, at least in games. There's only so many places to go with that kind of story, so I'd love to see a different hero type.
What worries me the most about your statement, however, is that you say "for this day and age". What I can glean from your writing suggests that you are suggesting that we put handicapped characters in for political correctness instead out of any actual in-game justifications for doing so. It reminds of the the ME3 gay options being introduced, which don't have any actual in-story justification (unless only new characters are presented as options), because people think about satisfying individual groups instead of focusing on creating greatness. I hope that I'm misinterpreting you here, but I want to know why, for gameplay/story reasons, you think that this sort of hero can really offer something new.