I don't like Death Note. Sure, the characters are a little cool, but as for the story, well... I mean, a book with the power to kill anybody's name you write in it? It's kind of meh for me. Rurouni Kenshin, though I haven't really watched it or anything, doesn't seem too appealing to me. Blood+ and Hellsing also fall into that category.
On the other end of the spectrum, though, any anime that doesn't really take itself seriously (Axis Powers Hetalia, Lupin the III, Bo-Bo-Bo-Bo-Bo-Bo-Bo, One Piece, etc.) I usually can take solace in.