It's already been mentioned more than once, but the Fade from DA: Origins. I think it deserves special mention because the last I checked, one of the highest rated and downloaded mods for DA:O on nexus was the Skip the Fade mod. That says something...
Anyways, in Assassin's Creed 3, the endless chase scenes with insta-fails and pointless side objectives scattered through them can fuck right off.
Also already been mentioned, but the ending to L.A. Noire was just bloody stupid.