Honestly, no ones said Shadow of the Colossus yet? Your in the Forbidden Land, and it damn sure lets you know your not welcome there. There's no life around. We never learn why the Forbidden Land is the Forbidden Land, but the isolation of being well and truly alone makes it feel tragic, almost apoclyptic. And then the Colossi. Large, Magnificent creatures, closely enough to what regular animals look like to actually feel alive. And your tasked with killing them. They're just wandering the Forbidden Land, for god knows what, not harming anything, and your tasked with killing them. you are the invader, these things did nothing against you, you are a murderer. To quote Tycho from Penny Arcade:
"The dread starts at the very beginning, simmering in your gut, and it never gets better ever - hour upon hour. You know immediately that you are engaged in something like evil, if not evil itself, but our appetites as players demand that we seek objectives and conquer them - and the game scourges us for this dereliction of conscience. The technology at work often obscured the game itself, but the emotional wavelength has resounded years after the fact. At this late hour, I can recall no camera foibles or performance valleys. All I can recall now is the black bargain, and concentric waves of anguish."