Best NPC in any game

[MiracleOfSound]

Alyx. Alyx. Alyx.

Three Dog can go choke on his microphone.

 

[Bendebec]

Moira in Fo3.I am gonna get my ass kicked for this one.

Seconded, some of her dialouge is actually good. Her or that tree in oasis, I like him, so I didn't kill him.

 

[Aerodynamic]

Dogmeat
Fallout 1

 

[Fingolfin High-King of the Noldor]

Deckard Cain from Diablo.

 

[Vriggchan]

HK-47 best NPC ever!

 

[Z of the Na'vi]

Ashley Williams, she was damn fine. So sexy

Had to think about that for a minute. I thought you meant the dude from Evil Dead...

 

[rasmusernst]

Murray! From monkey island.

The demonic skel... uh... The mighty demonic SKULL!

http://www.youtube.com/watch?v=V9xLoTXC5fk
http://www.youtube.com/watch?v=LMi2Il6iRks

Either him or Wrex from Mass Effect.
http://www.youtube.com/watch?v=Ln5mZ-uTMNI

 

[Kajt]

"M'Aiq knows much, tells some."

 

[GrinningManiac]

Pey'j from Beyond Good and Evil was good.

I still remember how he would randomly threaten you if you bashed his hovercraft about.

"Yer Crusin' fer a Brusin', Jade!"

 

[Stickynote74]

Gaz

 

[Jamash]

My favourites are

From Jade Empire

1. Sir Roderick Ponce Von Fontlebottom The Magnificent Bastard (voiced by John Cleese).
2. Qui the Promoter (an idiot who misuses words in an attempt to sound intelligent).

and from Oblivion

3. Lord Rugdumph (another idiot who misuses words in an attempt to sound intelligent).

As you can probably tell, for me humour is the most important quality in a memorable NPC.

 

[Dr Ampersand]

I second Father Gregori as he was nice, polite, he gave you a FREE shotgun as well as having a maniacal laugh and a moment where he walks through fire shooting zombies which earns extra brownie points.

 

[Portkins]

Ignus from Placescape.

 

[JFenlon]

Gaz

Agreed, i cried when he died.

 

[Sev72]

Basically everyone from the Kotor franchise. Also Sev and Fixer with their constant back and forth were pretty awesome.(Star Wars Republic Commandos)

 

[Xbowhyena]

Tom Nook!

 

[rowan-thats-me]

dunno if it counts but the cultists in DOW

just because they shout(well it sounds like anyway) OW! MY SPLEEN!

 

[zerzxes]

Shodan system shock games. Lo-lo-look at you hackker p-pa-pathetic
Creautre of meat and bone,panting and sweating as you r-run through my corridorss, how can you challenge a perfect Immortal machineeech.
also Dogmeat from any Fallout game needs an mentioning

 

[Eatspeeple]

Dog in HL2, I just love watching him jump around...
I feel I should qualify that but i can't think how