Best NPC line ever said

[Th3 Sh00ter]

Dont remember who said although I know they were British (CoD4):

"Ugh! He's gotta be taking a piss!, We just busted our asses to get all the way up this hill and now he wants us to go back down!!!"

 

[xXzykoXx]

"Oi, Suzy" Cpt. MacMillan CoD4
or if cutscenes count
"War, war never changes" Fallout games

 

[Uberjoe19]

"Sometimes I dream... about cheese."-Half-life 2

 

[Necrophagist]

"Did you know the human body can survive without a stomach or a spleen? Oh, hey there."

- The Sarah Palinish chickey in Fallout 3. I forget her name. She was AWESOME though.

 

[Worr Monger]

"Hail traveler, Can I... interest you in charmed beast to accompany you on your quest?... These wolves are strong and well-worth the meager price of $200 gold..... YA WANT ONE!?!?!??!"

-Henrick from Nox

 

[Simriel]

Every line by three dog in fallout 3.

 

[Necrophagist]

Thanks for listening, chillll-drenn! This is Three Dog, awoooooooooo!

 

[hazabaza1]

"DEATH IS AN ACCEPTABLE ALTERNATIVE TO COMMUNISM." I loved liberty prime.

Also, in saints row 2 when hi-jacking cars, I love when my character goes, "you got insurance? Good.: Or, "What the hell are you doing in my car?"

 

[this_was_a_mistake]

GTA IV
Roman: "I don't want to die, man, not like this!"
Niko: "How would you like to die?"
Roman: "uhh...maybe a threesome on my 100th birthday?"

 

[Metalchair]

a brute from halo 3 once said "He was my lover!!!" when i killed a different brute. i died because i was rolling on the floor laughing

 

[RazerSauber]

"You want guarantees? Buy a toaster!"

Captain Catastrophe from Crysis (Can't remember his name)

 

[Aptspire]

"All your base are belong to us"

Or does that not count?

Other favorite is probably from Portal

Glados about the companion cube "Maybe you should marry that thing since you love it so much. Do you want to marry it? WELL I WON'T LET YOU! How does that feel?"

LIES! she says it about the anti-neurotoxin gas sphere (purple)
But I agree, Glados' lines were genius !
also: "Remember when you were sliding into the fire pit and I said 'Goodbye'and you were like 'NO WAY!' and then I said, we pretended we were going to murder you?
...
that was great"

 

[theCMNDER]

"Use the boost to get through!"

 

[owlet]

"Welcome to quake 3 arena. Jump here to reach the armor. Enter the portal to fight crash" - Quake 3 announcer on the shortest tutorial level ever.

 

[CallmeMerry]

"...But our princess is in another castle!" Don't need to say where that's from.

 

[damselgaming]

I don't know if it really counts as an NPC, but when I was younger I used to love the Age of Empires 2 taunts.

"All hail king of the looosers!"
and
"Nice town. I'l take it!"

 

[USSR]

In GTA: Vice City once, I was walking down a road "behaving myself"

...Sadly, I can't walk down a street behaving myself.

My game is glitched to the point where all the NPCs have weapons and are on a mortal rampage against each other.

..but it is ever so fun battling an old lady with a missile launcher ^^

 

[DND Judgement]

"don't worry i won't hurt you..." - glados

 

[L4Y Duke]

Erk: "Oh great, you're the last person I wanted to see."
Serra: "Oh, that's so sweet, you wanted to see me again".
-Fire Emblem (The first GBA one)

Ooh, I just had to go onto Wikiquote to get this one!

"Frail? You? Serra, you have no need of any escort to protect you. Even the most hardened criminal would flee in terror after five minutes in your company. I'll return your money. Gladly. Now, will you please go on to Ostia alone?" - Erk

 

[Theon Tonarim]

"Cheesy vaginas!"
- A number of random citizens in GTA 4.