Best way a video game broke the 4th wall.

[SangRahl]

Sam & Max Hit the Road:
Spend a minute or so randomly clicking around the screen and Max will start gibbering and acting like a the pefect candidate for a straight jacket fitting. Sam consoles him and says to you (paraphrased), "See? Look what you and your incessant clicking has done to poor Max."

This was one of my favorite exchanges in a game absolutely packed with great dialogue.

Full Throttle:
Using the mouth "talk" icon on random object has been say, "I'm not putting my lips on that."

 

[IxionIndustries]

"Pressing down will make me crouch! If you move back and forth, you can make me do the duck walk!"

Oh god what game is this, this sounds so familiar I need to know now.

I can clear this up for you:

Spoiler

 

[Iwata]

"Pressing down will make me crouch! If you move back and forth, you can make me do the duck walk!"

Oh god what game is this, this sounds so familiar I need to know now.

I can clear this up for you:

Spoiler

AAAAAAAAAAAAIIIIIIIIIIEEEEEEEEEEEEEEEEEEEEEEE!

 

[Baneat]

MGS1, with the game manual thing, the stealthy walk thing, and the disk switch.

 

[The Warden]

MGS4, when Otacon and Snake start talking about Blu-ray discs or whatever.

 

[TheYellowCellPhone]

Conkers Bad Fur Day: Live and Reloaded had several. Here are the ones I remember:

Remeber the gargoyle on the bridge? If you haven't played, the solution is to walk up to the gargoyle and hit it with a frying pan, where it insults you for the stupid idea, then for some reason falls off the bridge.

In Live and Reloaded, doing that will result in the gargoyle saying the same line, then finishing it instead of falling off like in the original it goes something like:

Conkers: Weren't you supposed to fall of?
Gargoyle: Yes, but the developer didn't want everything from the first game to be the same.
Conkers: (Thinking to self) It's a good thing I brought the baseball bat.

Whereas you hit the gargoyle with the bat and it falls off.

Conkers: Hey developer, keep everything the same, okay?

A minor one too: In the prehistoric section of the game, when you first enter the area where the gigantic stone dragon is, Conkers says something along the lines of "The music doesn't fit. Hey mistro?" Then different music starts playing.

 

[SteakHeart]

In the ZP review of duke nukem forever he mentions that for a while u can control dukes neck with the six-axis controller until duke nukem breaks into the lead developers office and punches him in the face


-nough said

You know he was being sarcastic, right? Duke Nukem Forever was cancelled.

 

[Onyx Oblivion]

M'aiq The Liar. Everything he says.

 

[sneeky033]

when you first talk to Atton at the beginning of star wars knights of the old republic 2, he randomly mentions how he was originally planned to be cut from the final version of the game. not exactly funny, but pretty perplexing

EDIT: HOLY CRAP I ALMOST FORGOT:

there's this one room in the free indie game I Wanna Be the Guy where an error message flashes up in the middle of the screen, then falls, crushing the player. it's one of the funniest moments in the whole game. (good luck getting that far)

http://kayin.pyoko.org/iwbtg/downloads.php

 

[Canadamus Prime]

Also from Sam & Max: Hit the Road, if you continually try to pick up something that you can't pick up, Sam will turn to address you and say "Read my lips 'I-CAN'T-PICK-THAT-UP!'" And if keep doing it after that he'll evertually start whimpering and Max will address you saying "Now look what you've done, you've broken Sam's spirit. If I didn't find is whimpering so amusing, I'd come out there and rip your arms off."

 

[Orcus The Ultimate]

Omikron the nomad soul... since i remember it from another topic...

 

[Hristo Petrov]

My god how come no one has said The bridge of death in Fallout 2 not only that it breaks the 4th wall by having your character tell you "I think I should save my game in a different spot" but it's also a reference to Monty Pyton and the Holy Grail. Come to think about it Fallout 2 had a lot 4th wall breaking moments but Im to lazy to write them all.

 

[Dr. Wily III]

The only one I remember right now is Snatcher when Gillian looks at his apartment.

Edit:

Also from Sam & Max: Hit the Road, if you continually try to pick up something that you can't pick up, Sam will turn to address you and say "Read my lips 'I-CAN'T-PICK-THAT-UP!'" And if keep doing it after that he'll evertually start whimpering and Max will address you saying "Now look what you've done, you've broken Sam's spirit. If I didn't find is whimpering so amusing, I'd come out there and rip your arms off."

Argh, this one was hilarious!

 

[Bi Polar Bear]

Definately the Paper Mario series. On more than one occasion, a character (Peach or Clump for ex.) will turn to the screen and address the player, much to the 'wtf' looks of other characters.

 

[The_GrimSweeper]

In the Futurama video game, the first task you get is to find a hammer for the Professor while playing as Frye. The hammer is on the bottom of a pile of a bunch of heavy stuff like a piano and a refrigerator, and once you grab the hammer the stuff falls on you and kills you. The screen turns black and says game over, then you pop up in some toaster device in the lab. The professor explains to you that he did that as a test to try his new instant cloning device, and Bender tells you you died, and asks what being dead was like. Frye says, "Well, everything went black, then suddenly big white letters appeared and said Game Over."

One of the funniest moments I remember in a game.

 

[Bodyless]

Baiton Kaitos definitly had the best plot twists ever...
Anyway, from the warcraft III sorceress, roughly translated into english:

"Lets chat in Battle net"
"You dont get out often, do you?"

 

[thepopeofatheism]

I'm going to have to throw MGS3 into the ring here:

Sigint: Snake, what's up? Why are you naked? I know there's a "NAKED" option under "UNIFORM" that lets you take off the upper part of your uniform. But without a shirt on, your camouflage sucks, and your stamina goes down faster. You don't get any advantages whatsoever.
Naked Snake: Sure there are.
Sigint: Like what?
Naked Snake: It feels good.
Sigint: ...Man, you do whatever you want.
Naked Snake: I will, thanks. Just one question, though.
Sigint: What?
Naked Snake: Is there a way to take off my pants?
Sigint: Say what?
Naked Snake: My pants, can I...
Sigint: Aw, hell no! This FOX unit is a nut fest!


Colonel Campbell: [after "accidentally" killing Ocelot] Snake, what have you done? You've changed history. You've created a Time Paradox!


Sigint: [regarding the Soviet camo] Looks like Soviet guards will hesitate to attack you from behind with this on.
Naked Snake: You mean it has advantages, other than being stylish?


Para-Medic: [On the radio] Snake, have you seen "007: From Russia with Love"?
Naked Snake: I don't like those movie. Real spies are nothing like James Bond. It's pure fantasy.
Para-Medic: Snake, I don't think the Major's going to like you saying that.
Naked Snake: And even though it's fiction. I can't help but comparing myself to Bond.
Major Zero: What exactly don't you like about James Bond? Is it the fantastic gadgets? The cars? The guns?
Naked Snake: Major...!
Major Zero: Snake, wouldn't you like to have a gun shaped like a pen?
Naked Snake: What good is a pen going to do me in the jungle? I'd look like a fool.
Major Zero: Then what about a snake-shaped gun? You could make it look like you're grappling with a giant snake and then get a shot in on the enemy while they're distracted.
Naked Snake: Ok, now you're being ridiculous.


Sigint: [if you call Sigint while wearing a cardboard box] Uh,Snake... what are you doing?
Naked Snake: I'm in a box.
Sigint: A cardboard box? Why are you...?
Naked Snake: I dunno. I was just looking at it, and suddenly I got this irresistible urge to get inside. No not just an urge - more than that. It was my destiny to be here; in the box.
Sigint: Destiny...?
Naked Snake: Yeah. And then when I put it on, I suddenly got this feeling of inner peace. I can't put it into words. I feel... safe. Like this is where I was meant to be. Like I'd found the key to true happiness.
Sigint: ...
Naked Snake: Does any of that make sense?
Sigint: Not even a little.
Naked Snake: You should come inside the box... Then you'll know what I mean.
Sigint: Man. I don't wanna know what you mean! Between you and Para-Medic, is everyone but me that is hooked up with the Major strange?
Naked Snake: ...
Sigint: Yeah, well, anyway. I suppose even that dumbass box might make a decent disguise if you wear it inside a building.


Sigint: From the looks of it, it's fitted with a 100-round drum magazine... and it never runs out of ammo?
Naked Snake: Never.
Sigint: Why's that?
Naked Snake: Because the internal feed mechanism is shaped like an infinity symbol.
Sigint: Ah, I get it. Yep, that'll give you unlimited ammo.

Dammit...I can't find a transcript of the hilarious one about the glowcap mushrooms.

 

[Nothing Tra La La]

I agree with the MGS and No More Heroes ones. Hurr.

I'm surprised no one has mentioned Silent Hill 3. If you have a game of SH2 saved on your memory card, at one point in the game you urge Heather to reach into a grimy toilet, and she responds with something along the lines of "This is disgusting! Who would do something like this?!"
On my first playthrough, lulz ensued.

Also, I don't know if it counts, but in the introduction case against Dahlia and Phoenix in Phoenix Wright: Trials and Tribulations, Mia becomes astonished when the judge and Winston Payne are extremely defensive of Dahlia. She thinks to herself, and I quote, "I guess we know who's milkshake brings all the boys to the yard..."