Worst: I Wanna Be The Guy
Ok seriously what the fuck? I have never heard of this game and so many people here refer to it ever now and then, what kind of a retarded title is that!? When I first read it I honestly thought someone was making it up.
Best: Most of the Castlevnia games have awesome subnames:
Symphony of the Night, Aria of Sorrow, Lament of Innocence, Curse of Darkness, Portrait of Ruin, Order of Ecclesia, Harmony of Dissonance, Circle of the Moon
and many more.
Either those or Prototype, I dunno but I really like the word so I like that title a lot.