Assuming you got the PC version, check out the Nexus [http://www.newvegasnexus.com/] for many invaluable mods to help the little problems, like text size taking up more space than necessary, and my personal favorite as of now, Wasteland Settler.
If you haven't played a Fallout game before, here's the best tip anyone can give: Caps are the main currency in the game.
They are not trash.
Also, repair your guns and armor with other guns and armor of the same general type (clothes repairs clothes, leather repairs leather, pistols repair pistols). Never explained if you don't like reading a lot.
If you want to use energy weapons, wait until you actually arrive in Vegas before putting any points into the skill. The Van Graffs are the only reason they're a sensible option in this game, otherwise the weapons would just be so damn hard to find they'd be stupid (or just plain expensive) to use.
If you're going to fight people in armor, either use a melee weapon or take out the armor piercing rounds. Personally, a good sledgehammer is my cup of tea to fight the Legion. Or NCR. Depends on my character, really.
If you'd rather avoid a fight where possible, investing in speech is not a bad idea. Especially once you get in a few levels and have points to spare.
Medicine is also a good skill. Less stimpaks used, less money spent, more money for guns, armor, ammo, and gambling.
For the love of god, if you see a Deathclaw, and you do NOT have ammo to spare, lots of stimpaks, and a powerful long-distance gun, get the fuck out of Dodge. They will mess your shit up faster than a decapitation.
Lastly, don't finish the main quests (Mr. House, Yes Man, NCR, or Legion) until you think you've explored the last bit and done all the quests you can in the Mojave Wasteland. The game doesn't allow afterplay, and it also makes the ending so much better.