From No More Heroes, we have:
Bad Girl, once she gets the flaming bat; Holly Summers, when she uses that goddamn missile spam thing; Shinobu, if you're using the Tsubaki MK1 or blood berry...and the two secret bosses: one with the Triple-Decker-God-Hand-Flash-Step-Royal-Release-Samba-a-la-Flambe, and the other with the Omnislashing-Juggle-Combo-Teleporting-Ground-Pound-Plus-Dick-Punch-on-the-High-Seas and charge-up instakill.
From Divinity 2: Ego Draconis, we have:
EVERY SINGLE ENEMY IN THE ENTIRE GODDAMN GAME (unless you do the sidequests, in which case you can beat the final boss, his ensemble, and the previous twenty-man-boss-rush in just under four minutes and forty seconds).
And from Devil May Cry, we have:
Dante, the second time you fight him
Dante, the second time you fight him on hard and DMD modes
THE MOTHERFUCKING DICE.
Bad Girl, once she gets the flaming bat; Holly Summers, when she uses that goddamn missile spam thing; Shinobu, if you're using the Tsubaki MK1 or blood berry...and the two secret bosses: one with the Triple-Decker-God-Hand-Flash-Step-Royal-Release-Samba-a-la-Flambe, and the other with the Omnislashing-Juggle-Combo-Teleporting-Ground-Pound-Plus-Dick-Punch-on-the-High-Seas and charge-up instakill.
From Divinity 2: Ego Draconis, we have:
EVERY SINGLE ENEMY IN THE ENTIRE GODDAMN GAME (unless you do the sidequests, in which case you can beat the final boss, his ensemble, and the previous twenty-man-boss-rush in just under four minutes and forty seconds).
And from Devil May Cry, we have:
Dante, the second time you fight him
Dante, the second time you fight him on hard and DMD modes
THE MOTHERFUCKING DICE.