Personally I'm into Inquisitor. Granted it is part of the Warhammer 40,000 universe, so sci/fi rahter than fantasy, but I've tried so many other P&P RPG's and this is just, in my opinion, perfection.
Where as in D&D (I play 3.5) everything has a dice roll, of some various number of sindes, to decide the outcome, along with some aspect of your characters stats, leaves very little room for creativity and leeway. Though at the same time, having that much structure is helpful if you're not too creative yourself.
Don't get me wrong you can do a hell of alot in D&D, I'd say with all the different monster and quest books there's near enough infinite possibilities, but I just found having a dice roll for any action or reaction a bit... overbearing! (anyone know what I mean?!.)
But yeah! Like I was saying. I find Inquisitor works the best. You only have D10 and D6 to worry about. Granted yes the odd D3, but that is just halfing a D6's results. The universe is so vast and varied, with all the character classes and skills and equipment you can choose from, the character customisation is huge.
D&D may have rules to govern the appearance, but that's one of my complaints. I hate having so much left up to chance. I like a little more certainty with things. If I want to have a 6'2"//151lbs//bald//scarred//grizzled Inquisitor in a huge coat with a giant sword I can have it. Rather than ending up with an ancient fat short human with a pet pig and loin cloth. (I know I took that a little far, but it feels like that sometimes)
You can create anything you like in the Inquisitor universe, as you have an entire galaxy of planets and creature to choose from. You don't even have to just work from the WH mythos, you can add to it without having to use stats tables, just so long as the resultant super mutant or daemon isn't too over the top. Or hell make it that damn hard and evil, so every warband on the table has to run like hell to not be killed in bloody violent mess.
The dice system is really simple and it's all easy to get into. There's alot of player//GM discression in the way things can go, though the GM will always have the final word, of course. My only problem is the damage system is a little awkward sometimes, you can end up with everyone dying in a couple of seconds from over powered cleaves, or everyone becomes a space marine and just walks through hails of bullets without a second glance. It's fun, and that uncertainty makes you cautious, a lovely added psychological element.
So if the sci/fi element doesn't bother you, go for it, it really is something else at times.
Hope my opinion and zaelous referal has been of some help.