Watch the Dante's Inferno animated film and do a shot everytime he says "Beatrice" and a double if he shouts it. I guarentee you'll be knocked out by half-way and enjoying it a lot more than you otherwise would.
Or there's the Unreal Tournament drinking game:
If you're playing bots, then drink everytime you die and see how long you last (difficulty level of your choice).
Against friends then treat the drinking like a handicap, and make someone drink a shot for a killing spree, 2 for unstoppable etc, finish their drink for winning a round. Drink when killed by the Redeemer or finish drink when killed by Impact Hammer - there's lots of rulse you can think up