Well, since spoilers are already a given...
1. I'm hoping for the villianess (codename: Bitemark) at the end of Case West to give a better reason for her deeds than because she used to work at Umbrella, which looks to be the case.
2. The ability to carry around at least a little ammo. Guns aren't very useful anyway, I can understand Mr motocross champ not being an expert on firearms, but apparently all Frank learned covering wars was where to find the fucking trigger. (then again, he can use a butterfly trigger one handed, which I'm told is impossible)
3. It be nice if they could put in a "wait for next mission" function. I liked faffing about with zombie genocide by way of whatever I got my hands on, but sometimes you just want to get on with things, I think.
4. Some explanation as to how the hell Frank infiltrated Fortune city and found Chuck at just the right time. I'm aware that, of all the silly things in the story, that shouldn't bother me much, but still I find it vexing.
5. If they bring in a new protagonist, how about someone who's actually characterized to fit the part? You see anything wierd about frank or chuck doing the kind of crazy shit (moosehat charge) you can do, but always acting normal? Maybe I'm not phrasing it right, you know how the Boss in Saint's Row 2 was crazy as a soup sandwich? (trust me, all 6 voices have the same cutscene dialogue) That fit perfectly well as the kind of person that would go car surfing, assault someone with defibilators, or mix radioactive waste into tattoo ink.
I don't think Dead Rising has that, the protagonists we're given seem like sane, level-headed people most of the time, or is that just part of the joke?
EDIT: Damn, nearly forgot:
6. Balance out the fucking difficulty a bit.
7. Maybe make bosses more than "Whack when vulnerable, run away from their unbreakable attacks, repeat"