We will only encounter massive changes through technology, which is sort of our new evolution by proxy.
Biologically, though?
Women will have larger breasts, Men will have longer dicks. This is because most men want larger chests, and most women want longer penises.
These are the only aesthetic definite changes, though- perceptions of beauty change from generation to generation (In fact, we all tend towards the general beauty desired of the generation before us), and so other features are not necessarily going to be spread very far.
I expect basics, like lung and heart health, will improve over time. Maybe we'll gain a stronger resistance to harmful chemicals like tobacco- though I'm not sure about that one, as only so many people actually smoke often enough to be at any imminent death risk.
Most importantly, you can be assured that we will remain humanoid, with no major alterations- because of our obsession with beauty, it is unlikely that most will be willing to breed with a "deformed" person, even if that deformed person is somehow superior.
In other news, did anyone hear about that snake with an arm? It was actually using it to crawl across a wall, at least until it was killed... So much for man-snakes.
EDIT: Oh, right- I almost forgot the most important part! The good news:
We do not evolve significantly anymore, because... We are as evolved as we need to be!
Evolution exists to allow adaptation to ones environment. WE adapt the environment to OUR needs, and so we have evolved past the need for the natural selection process- technology can easily be used to fill in any blanks, like medical conditions and whatnot.