Heh, guess they should've named this one Fallout 3, and FO3 should've been Fallout: The Capital Wasteland. I just hope that this modern generation knows a bit about FO1&2. Because if they don't get any of the references, they may be kind of confused with no tie-ins to FO3, other than the occasional faction mention, and the super mutants. I wouldn't be surprised if a lot of people are disappointed just because the references to the previous entries into the series are older than they are.
Also, If Obsidian keeps the Fallout IP, or if it goes handed back to Bethesda, I wonder how FO3 will tie into canon. If Bethesda gets it, I'm pretty sure FO3 will stay canonical. If Obsidian keeps it, who knows? I'm interested to see how that all goes.