New Vegas doesn't offer clean-cut "easy" choices.
The NCR comes closest to recreating pre-War conditions, and this isn't saying much, considering how those settlements it rolls over in its expansion are either destroyed or absorbed and stuck to redirect their resources towards the greater mass, instead of the local community.
The Legion offers support, sure, but Caesar's vision of Roman society is horribly skewed thanks to the only bits of known history remaining being found in a handful of books and Hollywood recreations. Everything we can credit the Romans for, he stomps on. All he cares about is power and absolute control - which is something that's hard to maintain once the man that was holding it dies.
The Brotherhood of Steel is obsolete and in no way related to the nice and congenial "renegades" from Fallout 3, with their more humanitarian goals. The Great Khans are a group of bandits and drug peddlers.
Then there's Mister House, who can't look for anything else other than Number One's profits, viability and maintained power. The rest of the Mojave can crumble apart for all he cares - only Vegas needs to endure.
If you go with Yes Man, all of these groups end up shafted and you're placed in power, effectively securing a situation that mirrors House's, except for where a living, breathing human is going to offer a face for those in the Mojave who seek governance to look at. The Courier won't last as long as House, obviously, but maybe he or she doesn't need to.
No matter what you pick, innocents will die. Some people will suffer no matter what stakes you consider. New Vegas isn't like Fallout 3 in the sense that there isn't one clear-cut faction to consider if you feel like "winning" the game as a good guy.
The one option which, in my very humble opinion, seems to mitigate losses adequately would be the NCR. I've never been a fan of Scorched Earth tactics, and House's goals don't sit too well with me. The Brotherhood's a bunch of bigots and the Legion rewards moral depravity.
If all you're concerned about is political or social stability, however, then take your pick. Each of the factions offer the same potential as the other.
Mostly because I am obsessed with junk and wanted access to all the safehouses. (NCR, Legion, BOS, and Follows of the Apocalypse?) 
