I'll always be fond of the Stim-paks from Fallout 3. It fits in well when you're role-playing, and I always seem really happy when I stumble across one, even if I have a dozen or so in my pack already.
I liked Phoenix Down from FF, it's sort of a healing item, well, more of a ressing item, but it does heal you a small bit on top of that, and the name was just always awesome in my opinion.
The food in Bioshock 2, but only after watching the zero punctuation review where he talks about squishing it against your faceplate. "Unless Adam allows you to magically absorb food from the ether!"
Pretty much any health item in Disgaea. I can't think of them off the top of my head, but every item has its own little description, and they're usually pretty funny.
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