I really dig Jim Gaffigan. I think he spawned what I like to call "Lazy Humor". I like Daniel Tosh too, although he gets pretty out there. Brian Regan is good for a comedian who does his best to be clean with his humor. Mitch Hedberg was great while he was alive. I think Brian Posehn has some great stand-up. And Demetri Martin is definitely up there. Dave Chappelle is good, if not just for the fact that he makes traditionally Black humor topics more accessible to a bigger audience.
I've seen a couple of people call out Jo Koy, but I could never get behind the guy. I even went and saw him live, and didn't really laugh all that much.