I read a lot, so bear with me while I try to organize things. Basically, when I get into webcomics, I look for two really big important things: Characterization and Story. I'm also quite partial to comedic webcomics simply because my life is dreary and stressful.
My favorites, the undeniable gems:
Questionable Content = I just finished reading this and loved it. It has amazing characters and the kind of humor that's right up my alley. The story expands upon itself and it?s one of the few webcomics I've read that hasn't lost its sense of humor in favor of drama over the years. Even the latest strips have consistently made me giggle and thus I cannot get away with reading it in class instead of paying attention to lecture.
The Phoenix Requiem = Absolutely beautiful artwork and it also gets props for a gripping story. It's a Victorian romance/supernatural fantasy, and a must-read if you need something a little more serious.
Girl Genius = Awesome. There are a lot of characters, yes, but each one has their own little role to fulfill. Just like in the Harry Potter series, even the minor characters have some importance, and the story would not be the same without them. It's a mix of steampunk and fantasy with a storyline that's very original (you rarely find ?original? these days). It too is another comic that has been around a while and not lost its touch.
Something Positive = Cynical humor, 'nough said. Love it! It has all your essential mockery of life's woes.
Order of the Stick = I have never even played D&D and this webcomic sparked an interest in me in perhaps learning how-to someday. Burlew is a fantastic storyteller, and like the comics above manages to hold on to his ability to mix humor and character development. The storyline maintains its comedic fun while not taking itself too seriously. Be prepared for a slow server, but I hear that problem is finally getting fixed.
xkcd = An intelligent webcomic. Its tagline, ?A webcomic of romance, sarcasm, math and language? is probably the best and easiest way to describe it.
The Dreamland Chronicles = CGI style, and very, very attractive, graphics. I could not stop reading once I started. Scott Christian Sava has created a truly immersive world that literally appeals to all ages.
**I pretty much love all of these above webcomics equally.
More fun reading:
Applegeeks = I'm not exactly an Apple fan, but I still enjoy and get a good laugh out of the story.
Johnny Wander = Enjoying it so far. It's a nice ?slice of life? type comic.
Fey Winds = snarky, doesn't take itself too seriously. I like where it's going in terms of the story.
Earthsong = the story so far is decent enough to keep me interested, but I feel like it's still budding.
Punch an' Pie (read Queen of Wands first since it comes first and is also a great read) = both comics are pretty funny, but do contain their serious points that deepen character development and make them pretty well-rounded in my opinion.
I check these on occasion for updates:
Megatokyo
8-bit Theater (sorry guys, it finally lost me when the story really seemed to wander aimlessly)
VG Cats
Penny Arcade
Rooster Teeth
I'm really unsure where to put Ctrl+Alt+Del. I do read it since it updates regularly but I definitely enjoyed the earlier comics much, much more. In a comparison, where Megatokyo made a somewhat smoother transition out of the humor genre Ctrl+Alt+Del decided to put on the brakes a little later, heavier, and with a more uncomfortable impact. Due to that, I can't really give complete thumbs up or thumbs down, but something more of an awkward horizontal wriggle. The characters don't seem to have the drama-bone in them required to handle some of the story arcs, in my opinion. From what I've seen of others' opinions, it's a ?like it or hate it.?
...that's my soapbox, but hey, I enjoy discussing my reading.