Garrus AGAIN? They'd better build upon some more internal conflict like "Leadership ability unlikely to flourish under Shepard's command" or his dying mother or disapproving father or something instead of lolcalibrations.
Interesting that Wrex isn't a squad member, or should I say, CONFIRMED squadmember. Who knows, he could be one if you complete the Krogan plot event.
Sadface that Mordin and Legion are being shoved off to the side. I couldn't really care less about Tali, but she will obviously be a huge part of the story (Admiralty Board mayhap?). Wouldn't mind seeing more of Samara or Thane, don't really care about Virmire survivor (Kaidan in my case), and Liara seems a little bit too derailed from her ME1 self. It's also kind of odd because she SHOULD be living in that mobile base.
As for game mechanics, it'd be really cool if they had a Deus Ex grid-ventory, even just for guns, but that's wishful thinking eh?
Kinda disappointed about the Reapers raining on Shepard's parade with the whole trial thing, I was hoping that it would really get dragged out. You have all of these conflicts between races, and to let the conflict of the player's race slide so easily seems like a massive cop-out. I'll be eating a bunch of rusty nails if they never even mention the Human-Batarian relations in the rest of the game.