Anachronox needs a sequel, it was a charming, funny and entertaining experience and one of the most memorable games I've yet to play.
Advent Rising, it was advertised as a trilogy and had a good story and an epic soundtrack, it had some problems but was still a good game overall, someone should really pick it up and make the remaining two games because it has more potential than most gaming franchises out there at the moment.
Oh, and I almoast forgot, Freelancer .. really great game, kinda thin on the simulation part of the space sim and more of a shooter really but that is the point, it was fun, fast paced, and just generally enjoyable ride, the story and characters were quite good as well and the soundtrack although a bit repetitive was good and at times key to creating the atmosphere and tension.