If we're talking about 100% achievements there are very few games I have this on, because they violate one of my rules of achievements:
1. Any game that requires I rely on another person to get an achievement. I absolutely hate this. Saints Row 2 required me to play the ENTIRE GAME in online co-op to get several of the achievements, not to mention the multi-player vs aspect of it.
2. Any lengthy game where getting the achievement requires an entire run through. When I finished Fallout 3, I went through it twice. All I had left were 4 achievements, all of them for having neutral Karma at various levels. 4 achievements is not worth another 40-50 hours of my time.
3. Any achievements that are unreasonably time-consuming or really boring. Any "get a ridiculous number of kills" achievements go in here.
That said, I've 100% Oblivion, back when I had the time for 3 playthroughs, and I am pretty sure I will 100% Borderlands, even though it had about 4 achievements that violate rule #1.