All they have to do is borrow my text books.
I mean, seriously. Art historians can really get up-in-arms over things, and setting a game in string theory would be pretty damn awesome.
That, or make a game about Marketing strategies. Then agian, visiting pre WW2 Japan would be pretty interesting, with the censorship, militairy coups, and the Buchenwald-esque island coal mines. Battleship Island would be a GREAT setting for most any genre of video game.