Ummm,
Anything on Xbox/PS that is an exclusive, I was/am a Nintendo fanboy, won't deny it I had a very bad childhood and Nintendo/SNES were my first systems and they got me through dark days.
I never thought I'd like Skyrim, but I got it via Steam Sale, and got addicted to finishing the faction/main quests, that being said I will probably not screw around with it after I finish. Maybe to play Dawnguard if it comes out for PC.
Anything by Rockstar, have issues with them and playability.
WoW, I used to play MMOs, but I quit, I only do flash based non grinding ones[by that I mean, like energy based I can hit and quit for a few minutes a day but even then I gotta find people to play with that I can talk to.]
Borderlands 1+2, I played a demo for it on Onlive, I didn't like it, too empty of a world feeling, too blandish for me.
Starcraft 1, Diablos 1+2, don't really care, tried their sequels. Pretty much a WoWish clone and a Blizzard RTS staple, I know and kinda enjoy for single player[cause I suck at multi in them, cause I can't be bothered to micromanage, I'd like to get laid one day]
Fighting games, I played Soul Cal... something or other, I think the one on CGN, it was okay but it was too... eh, I broke it against computers, I'd button mash, get them to ledge and ring out throw.
Half Life series, don't know, kinda didn't appeal to me to be honest when I had the chance to get it.
Any future EA title exclusive to Origin, I enjoyed Origin at one point early on cause my CD drive was broken and they had a digital download for even hard copy games if you had the CD key, so that saved my butt during Freshman year of college.
Original Dues Ex, old graphics after a certain number of years actually bothers my eyes, I don't know why it just does.
Duke Nukem Forever, okay I know it was crappy, but it was going to be a top seller at first purely for the lulz.
Amnesia, cause I'm whimpy even in games, I have a heart defect so jump scares actually do screw with me so I can't play those, only watch others play them cause I can laugh that way.
Lollipop Chainsaw/Shadows of the Damned, I love Suda 51, played Killer 7 and the NMH series, I love his quirk and charm, heard he just relies on that with those two, but ehhh I'll never get a shot with them.
Gears of War series, tried the first, got it for like $12, stopped playing after the first level, just did not like it at all.
Any future MW, Battlefield game. I played the first two of MW, and BF3[purely to see the other side's view] But both are too samey and shooter checklists.
Any sports based game, I heard they sell well, but any game that gets sold at full price for a roster update and a few new tricks, does not a new game make.