Spoilers lurk in my comment.
Games that have actually made me cry -
Gears of War 2 when Dom found Maria and had to kill her.
Devil May Cry when Mundus kills Gryphon...shut up I was young.
Devil May Cry 3 when Dante beats Virgil in the final battle.
Games that have left a hole in my heart -
Mass Effect when I let Kaiden Alenko die.
Mass Effect 2 when I lost Legion, Garrus, Thane and Mordin.
Gears of War 2 when Tai killed himself.
Halo Reach when Six dies.
God of War Chains of Olympus when Kratos has to leave Calliope in the Underworld.
Dragon Age: Origins when my character died and knowing that Leliana killed herself.
Modern Warfare when the terrorists were killing my squad, just feeling so helpless.
Games that have actually made me cry -
Gears of War 2 when Dom found Maria and had to kill her.
Devil May Cry when Mundus kills Gryphon...shut up I was young.
Devil May Cry 3 when Dante beats Virgil in the final battle.
Games that have left a hole in my heart -
Mass Effect when I let Kaiden Alenko die.
Mass Effect 2 when I lost Legion, Garrus, Thane and Mordin.
Gears of War 2 when Tai killed himself.
Halo Reach when Six dies.
God of War Chains of Olympus when Kratos has to leave Calliope in the Underworld.
Dragon Age: Origins when my character died and knowing that Leliana killed herself.
Modern Warfare when the terrorists were killing my squad, just feeling so helpless.