Yes, once. A friend of mine called me racist because I described some actor dude as 'exotic'. Which, to someone who grew up surrounded by absolutely nothing but pasty white northern Englishmen, he really is. She said that it was offensive to her because she's Hispanic and 'exotic' is a term used to describe animals. Personally it pissed me right off because, well, I've never heard her complaining about people being described as cute or beautiful or handsome, all of which are used to describe animals as well. In my eyes, exotic is just a word to describe someone with an appearance that the viewer is not accustomed to seeing very often. If I'd grown up somewhere where dark skin and hair is the norm, a pale blonde would be exotic too.
I didn't argue with her about it because, even if I think she was overreacting to absolutely nothing, people usually have a reason to feel offended by the things that offend them, and she's still my friend. Even so, I was very clipped while talking to her for the next few days. :/