Fallout 3 (never even seen footage from the two earlier ones)
Warcraft 3 (never played the ones before)
Bionic Commando (the newest one, haven't played it on NES or the Rearmed one)
Wolfenstein (also the new one, haven't played the older ones)
Overlord 2 (It's basicly the same, isn't it?)
Crysis: Warhead, for roughly one hour, then decided that I should probably play through the first one first.
Brothers in Arms: Earned in Blood (Have played the first BiA and BiA:HH, marvelous games)
Metroid Prime if that counts... Never was a fan of the sidescrollers (don't hate me

)
Dragon Age: Origins? Doubt the other Dragon Age games have anything to do though (at least so far) with Origins...
Command and Conquer: Red Alert 2
Metal Gear Solid 3: Snake Eater
Rayman 3
yeah, those are the ones that I can think of at the moment.