Nope. Never. I'm flexible and open minded like that, I adjust to any control scheme pretty quickly (or change it whenever possible), doesn't matter how crappy or convoluted it is.
I've played many Wii games and I just don't seem to be bothered by it, I've finished Okami, Metroid Prime Trilogy, Resident Evil 4 and Super Mario Galaxy 1/2 without much trouble (I haven't gotten to finish Skyward Sword due to lack of interest and NOT for the control scheme).
What sometimes turn me off is an unintuitive or archaic UI or gameplay mechanics, like many older PC RPGs, that's exactly why Baldur's Gate is nearly unplayable for me
EDIT: Although... well, Hammerfight for the PC absolutely has one of the worst control schemes ever devised for any platform, seriously, you need to move the frickin' mouse in circles with precise timing to control a clunky ship thingy, without taking into consideration the absolutely brutal and unforgiving AI. Fuck that game.