Jenny from The Darkness was a shocker to me, and hit me harder than I would have thought.
Alyx in Episode 2. I know, I know, she didn't die, but still. When that Hunter stabbed her, I couldn't even breathe for a second there.
Eli from Episode 2. That just sucked.
The Companion Cube. I'll always regret having not tried to find a way to save it.
Johnson, Halo 3. After having him live through so much (and especially after Contact Harvest) I really couldn't believe it when he died.
Andrew Ryan, BioShock. It's not that I cared at all for him. It's the way he died that stuck with me.
Alyx in Episode 2. I know, I know, she didn't die, but still. When that Hunter stabbed her, I couldn't even breathe for a second there.
Eli from Episode 2. That just sucked.
The Companion Cube. I'll always regret having not tried to find a way to save it.
Johnson, Halo 3. After having him live through so much (and especially after Contact Harvest) I really couldn't believe it when he died.
Andrew Ryan, BioShock. It's not that I cared at all for him. It's the way he died that stuck with me.