I wake up screaming at night...

[JaymesFogarty]

Isaac! Get the hell out of there!

I've got a feeling that, come January, a lot more of them will be heard.
On topic,
"Snake? Snake? Snaaaaaaaaaakkkkkkkkkeeeeeeeeeeeeeeeee?!"
"It's like...a... zombine. Get it? Zombine? Yeah..."
"Before you die, I'm going to tell you something, just so you really won't want to die."
"Would you kindly..."
"Shaun!"
"We live between the gloss, and reality, the Mirror's Edge."
"Requiescat in Pace."
"Where[bang]is[bang]my[bang]Mother?!"
Points for the person who gets them all!

 

[MasterSteef]

"I'm Commander Shepard, and this is my favorite store on the Citadel.", oh Shepard you are such a "Sell out"!.....because I made you that way!..MUAHAHAHA!

 

[CACAVILLE]

BLOAGNE AHAHAHAHAHAHAHAHAHAHAHAHAHA

 

[MasterSteef]

Its kind of obscure, but in Mass Effect 2 on Omega when the Batarian with his bodyguards stops you because he doesn't like you and tells you something along the lines of "Maybe i should have my boys here rough you up." So I picked a reply and Shepard does the most hilarious thing I've ever seen him do...

He walks forward, hefting his pistol from hand to hand in clear view of the Batarian and says in an awesome Clint Eastwood-ish tone "Do you see my gun?, Do you REALLY want to do this?"

I laughed so goddamn hard and still quote it regularly.

 

[Burningsok]

Idk why but I just find this quote funny from Gears of War 2

"Who wants toast!!?!?" - Marcus Fenix

and then there's RE4's Merchant

"Got some rare things on sale stranger."
"Aaahh, I'll buy it at a high price."
"Welcome."

I wish they had someone like him in RE5.

 

[Kuroneko97]

"Hey Niko, eet's your cazin, Roman. Do you want to go see beeg american teetees?"
-Grand Theft Auto IV


I also loved two speeches during the final boss of Final Fantasy XIII. They're a little long:

Spoiler: First Speech

"A haven, ye.
Yet it must fall ere we be saved.
Too frail a shell, and humans should not thrive.
Too stout a shell, and they will not die.
Slaughter and salvation! Two irreconsible focuses we bore.
Yet bound were we in a cocoon prison impervious to our power.
And so we thank you, for granting us our longed-for birth.
We are the Abandoned one, born but now to die.
Our name is Orphan. By our hand, the world shall know redemption."
-Orphan

Spoiler: Second Speech

"Have you ever paused to wonder our reason for making L'cie of men? We fal'cie are crafted for a single purpose, and granted finite power to that end. With men it is not so. Men dream, aspire, and through indomitable force of will achieve the impossible. Your power is beyond measure. We take L'cie that we might wield such strength. Through you, we obtained freedom from our bondage. And now, your focus alone remains. Defy it, and all will be for naught. Yet if we but summon the Maker, we will be granted a chance to begin again. All our sins, absolved, and the world-born anew!"
-Orphan

 

[Nanaki316]

"Your pain shall be legendary." - Arthas Warcraft 3. Epic line.

 

[Jfswift]

"The dragon is crying"

I've been playing FF IV: The After Years lately and like every chapter it goes to a cutscene where the elder says this line.. over and over..

I'll probably have nightmares about creepy summoner girls that can't be killed now.

 

[JayDig]

"GET OUT OF HERE STALKER!" -some douchebag at the bar
"DON'T JUST STAND THERE. COME IN!" -another douchebag at the bar

Good ole Stalker. So many characters, so few lines of dialogue.

 

[Dr.Nick]

"EVERYTHING IS SO SIMPLE WHEN YOU HAVE ROCKET LAUNCHER FOR AN ARM"

And pretty much anything from Tribes 1. Best voice acting for the time EVAR.

"The enemy has our SHAZBOT!"

 

[Caligulove]

"They're waiting for you Gordon... in the test chamber.."

Not only because the scientists said that all the time in the first 10min of Half Life, but it sounded creepy, with their inflection

 

[Kukakkau]

The Dark Sector shop owner never gets out of my mind.
'Look, It's my favorite half-monster customer!'
'Hey, it's yankee doodle, he's come to town!'

And now the memories of that horrible game are brought back from the far depths of my mind...

I'm surprised this isn't on the first page but "My cousin!! let's go bowling"
"What was that noise?!" - MGS
"He's going to hurt himself and when he does I won't help" Assassin's Creed
"Here we go.." - Wet
"He single handedly invaded a neutral country" - BF Bad Company

 

[googleit6]

"Nothing is True, Everything is Permitted" from Assassin's Creed

"Keep your eyes on those Geiger counters, kids. Tick tick tickety means 'run your ass outta there', and pop some RadAway for good measure..." Three Dog from Fallout 3. One of my favorite quotes from that game, though I don't exactly define the game by it.

"Kitty got wet!" From Uncharted 2. Apparently, Nolan North's niece used that phrase when she beat him on the wii, and he used it for Nathan Drake.

 

[SimpleChimp]

"These meat bags go down like sacks of meat bags"

"We are out of ammo, and Waddka!"

We have a friend named sam that we allways played nazi zombies with. The zombies really liked them. they were all "Saaam!"

"This is like gun i used to kill first wife. She was beetch"

"Stay Frosty" from COD. Cause every one needs to Stay Frosty.

"What kind of name is soap any way?"

"Damn it Bill! Stop shooting me"

"I lost a bomb, do you have it?"

"Lil' C4, Knockin' at yer door!"

"The human brain. It is a Pandora's box of electrical charges which we only begin to understand. Now, most brains are receivers, but some are advanced sending and receiving charges.
This is my Psychic Beacon. With it, we can send any message we want. We must construct this device everywhere, in the end the Americans will be ours. "

The Alert sound from any guard in any MGS game. (!)

 

[Theron Julius]

"I'm commander Shepard and this is my favorite store on the citadel"

 

[The_Deleted]

OOOENNDAAAAAAAAAAAAAAAN!!!!

 

[Scarecrow]

Gears of war, the line that says it all. The most said line in the game:
'oh shit'

 

[eggy32]

"I have FURY"
"I have chortles"
"Midbus will now fight and Fawful will help him... actually no, Midbus will keep his dignity and Fawful will watch"
"Easy as a bread sandwhich"

<3 Fawful

"Stop right there, criminal scum"
"I've fought mudcrabs more fierce than you!"

 

[Glass Joe]

"Food is good!" - Gauntlet Legends

 

[Zera_in_a_can]

"Perhaps you were expecting some surprise, for me to reveal a secret that had eluded you, something that would change your perspective of events, shatter you to your core. There is no great revelation, no great secret. There is only you." -Kreia, from Knights of the Old Republic II. She made everything dark and twisted... I bet the game would've been amazing if it wasn't rushed.